Dr. Zehra Edis is an Assistant Professor at Ajman University, UAE, since February 2014. She currently works with the Center for Medical and Bio-allied Sciences Research at Ajman University. With over 42 publications to her name, Dr. Edis has made significant contributions to her field. She holds a BSc, MSc, and Ph.D. in Chemistry (magna cum laude) from the University of Cologne, Germany. Born in Cologne, Germany, she combines her academic expertise with a passion for research and teaching. Her Ph.D. was awarded with a scholarship from the Graduiertenkolleg "Classification of Phase Transitions in Crystalline Compounds on Account of Structural and Physical Anomalies."
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The non-toxic inorganic antimicrobial agents iodine (I2) and copper (Cu) are interesting alterna-tives for biocidal applications. Iodine is broad-spectrum antimicrobial agent but its use is over-shadowed by compound instability, uncontrolled iodine release and short-term effectiveness. These disadvantages can be reduced by forming complex-stabilized, polymeric polyiodides. In a facile, in-vitro synthesis we prepared the copper-pentaiodide complex [Cu(H2O)6(12-crown-4)5]I6 2I2, investigated its structure and antimicrobial properties. The chemical structure of the com-pound has been verified. We used agar well and disc-diffusion method assays against nine mi-crobial reference strains in comparison to common antibiotics. The stable complex revealed ex-cellent inhibition zones against C. albicans WDCM 00054, and strong antibacterial activities against several pathogens. [Cu(H2O)6(12-crown-4)5]I6 2I2 is a strong antimicrobial agent with an inter-esting crystal structure consisting of complexes located on an inversion center and surrounded by six 12-crown-4 molecules forming a cationic substructure. The six 12-crown-4 molecules form hydrogen bonds with the central Cu(H2O)6 . The anionic substructure is a halogen bonded pol-ymer which is formed by formal I5− repetition units. The topology of this chain-type polyiodide is unique. The I5− repetition units can be understood as a triodide anion connected to two iodine molecules.
Despite the promising medicinal properties, berberine (BBR), due to its relatively poor solubility in plasma, low bio-stability and limited bioavailability is not used broadly in clinical stages. Due to these drawbacks, drug delivery systems (DDSs) based on nanoscale natural polysaccharides, are applied to address these concerns. Natural polymers are biodegradable, non-immunogenic, biocompatible, and non-toxic agents that are capable of trapping large amounts of hydrophobic compounds in relatively small volumes. The use of nanoscale natural polysaccharide improves the stability and pharmacokinetics of the small molecules and, consequently, increases the therapeutic effects and reduces the side effects of the small molecules. Therefore, this paper presents an overview of the different methods used for increasing the BBR solubility and bioavailability. Afterwards, the pharmacodynamic and pharmacokinetic of BBR nanostructures were discussed followed by the introduction of natural polysaccharides of plant (cyclodextrines, glucomannan), the shells of crustaceans (chitosan), and the cell wall of brown marine algae (alginate)-based origins used to improve the dissolution rate of poorly soluble BBR and their anticancer and antibacterial properties. Finally, the anticancer and antibacterial mechanisms of free BBR and BBR nanostructures were surveyed. In conclusion, this review may pave the way for providing some useful data in the development of BBR-based platforms for clinical applications.
The advancement in early diagnosis and precise treatments options result in more predictable and powerful health care modalities. Aptamers are known as nucleic acid structures with three-dimensional conformation to selectively bind a target site. Physicochemical properties of aptamers, their conjugation with nanoparticles (NPs) in theranostics applications and their internalization have been found to be of interest in development of aptamer-based drug delivery systems. Therefore, we aimed to present an overview on the structure and generation of aptamers followed by advantages of aptamers-conjugated NPs and their theranostics applications in various diseases such as oncology, inflammatory diseases and viral diseases. Afterward, we discussed several reports on the internalization approaches of aptamers, efficiency of aptamers vs. their analogous, and implications of aptamers in clinical trials. Finally, we discussed the current challenges and future perspectives of actively targeted aptamers for clinical application. In conclusion, this review may hold a great promise for development of aptamer-based therapeutic platforms in clinical trials.
Khan S., Cho W.C., Jaragh-Alhadad L.A., Tarharoudi R., Bloukh S.H., Edis Z., Sari S., Falahati M., ten Hagen T.L.M., Khan R.H., Bai Q. Nano-bio interaction: An overview on the biochemical binding of DNA to inorganic nanoparticles for the development of anticancer and antibacterial nano-platforms International Journal of Biological Macromolecules 2023, 225, pp. 544 – 556. DOI: 10.1016/j.ijbiomac.2022.11.110 https://doi.org/10.1016/j.ijbiomac.2022.11.110
Edis, Z.; Bloukh, S.H. Antimicrobial V-Shaped Copper(II) Pentaiodide: Insights to Bonding Pattern and Susceptibility. Molecules 2022, 27, 6437. https://doi.org/10.3390/molecules27196437
Zhang, W.; Cho, W.C.; Bloukh, S.H.; Edis, Z.; Du, W.; He, Y.; Hu, H.Y.; ten Hagen, T.L.M.; Falahati, M. An overview on the exploring the interaction of inorganic nanoparticles with microtubules for the advancement of cancer therapeutics International Journal of Biological Macromolecules 2022, 212, pp. 358 – 369.. DOI: 10.1016/j.ijbiomac.2022.05.150 https://doi.org/10.1016/j.ijbiomac.2022.05.150
Sharifi, M.; Cho, W.C.; Ansariesfahani, A.; Tarharoudi, R.; Malekisarvar, H.; Sari, S.; Bloukh, S.H.; Edis, Z.; Amin, M.; Gleghorn, J.P.; et al. An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment. Cancers 2022, 14, 2868. https://doi.org/10.3390/cancers14122868
Suliman Khan, Majid Sharifi, Jason P. Gleghorn, Mohammad Mahdi Nejadi Babadaei, Samir Haj Bloukh, Zehra Edis, Mohammadreza Amin, Qian Bai, Timo L.M. ten Hagen, Mojtaba Falahati, William C. Cho Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy. Journal of Controlled Release 2022, 348, 127-147, https://doi.org/10.1016/j.jconrel.2022.05.055
Edis, Z.; Bloukh, S.H.; Sara, H.A.; Azelee, N.I.W. Antimicrobial Biomaterial on Sutures, Bandages and Face Masks with Potential for Infection Control. Polymers 2022, 14, 1932. https://doi.org/10.3390/polym14101932
Desai, A.S.; Singh, A.; Edis, Z.; Haj Bloukh, S.; Shah, P.; Pandey, B.; Agrawal, N.; Bhagat, N. An In Vitro and In Vivo Study of the Efficacy and Toxicity of Plant-Extract-Derived Silver Nanoparticles. J. Funct. Biomater. 2022, 13, 54. https://doi.org/10.3390/jfb13020054.
Antimicrobial resistance (AMR) poses an emanating threat to humanity’s future. The effectiveness of commonly used antibiotics against microbial infections is declining at an alarming rate. As a result, morbidity and mortality rates are soaring, particularly among immunocompromised populations. Exploring alternative solutions, such as medicinal plants and iodine, shows promise in combating resistant pathogens. Such antimicrobials could effectively inhibit microbial proliferation through synergistic combinations. In our study, we prepared a formulation consisting of Aloe barbadensis Miller (AV), Thymol, iodine (I2), and polyvinylpyrrolidone (PVP). Various analytical methods including SEM/EDS, UV-vis, Raman, FTIR, and XRD were carried out to verify the purity, composition, and morphology of AV-PVP-Thymol-I2. We evaluated the inhibitory effects of this formulation against 10 selected reference strains using impregnated sterile discs, surgical sutures, gauze bandages, surgical face masks, and KN95 masks. The antimicrobial properties of AV-PVP-Thymol-I2 were assessed through disc diffusion methods against 10 reference strains in comparison with two common antibiotics. The 25-month-old formulation exhibited slightly lower inhibitory zones, indicating changes in the sustained-iodine-release reservoir. Our findings confirm AV-PVP-Thymol-I2 as a potent antifungal and antibacterial agent against the reference strains, demonstrating particularly strong inhibitory action on surgical sutures, cotton bandages, and face masks. These results enable the potential use of the formulation AV-PVP-Thymol-I2 as a promising antimicrobial agent against wound infections and as a spray-on contact-killing agent. Edis, Z.; Bloukh, S.H. Thymol, a Monoterpenoid within Polymeric Iodophor Formulations and Their Antimicrobial Activities. Int. J. Mol. Sci. 2024, 25, 4949. https://doi.org/10.3390/ijms25094949 https://www.scopus.com/record/display.uri?eid=2-s2.0-85192742942&origin=resultslist
Plants- and biomass-derived products promise health-promoting, biodegradable and sustainable properties for the increasingly health-aware consumers. Such products contain natural bio compounds, which can be exploited for improved benefits of available applications in public health, cosmetics, and medicine. Antimicrobial resistance (AMR) endangers global health and is responsible for the surge in morbidity and mortality cases. Alternative antimicrobial agents are impervious for the survival of mankind. Plants and biomass-derived products are naturally resistant since their existence against natural enemies and are able to defend themselves against opportunistic pathogens. We investigated formulations in our previous studies based on Aloe vera (AV) and iodine (I2). Both have been known for centuries as health-promoting, cost-effective antimicrobials and anti-inflammatory agents used against different ailments and in wound treatment. AV has many cosmetic and cosmeceutical applications. I2, a basic microbicide, is widely marketed in combination with polyvinylpyrrolidone (PVP) in the form of PVP-I, also called povidone-iodine. Povidone-iodine and AV are used for skin, nasal, and oral cavities as anti-infective agents in many cosmeceutical applications. Oral health and hygiene products like toothpaste and mouthwash contain AV and PVP-I. We studied previous formulations AV-PVP-I2, AV-PVP-NaI-I2, AV-PVP-Sage-I2, and AV-PVP-TCA-I2, where NaI is sodium iodide and TCA is trans-cinnamic acid. In this paper, we also mention our preliminary results of iodinated AV formulations with Punica granatum (Pomegranate). Pomegranate is widely consumed all over the world and renders the pomegranate peel (PP). PP makes 43% out of pomegranate fruit and is managed as a food additive or waste product. A mounting number of new investigations highlight its potential use in different applications due to its rich bio-constituents. We incorporated this biomass-based PP into our formulations AV-PVP-PP-I2 and studied its antimicrobial effects in disc diffusion (DD) studies against 10 common reference strains. We compared the results with our previous investigations and concluded their potential use as disinfecting agents in skin and oral cavities for the prevention of inflammation and surgical site infections (SSI). Further investigations are needed to verify the in-vivo uses of the studied iodinate AV formulations. Biomass-based Cosmetics Research Trends and Future Outlook Iodinated Aloe Vera Formulations for Antimicrobial and Cosmeceutical Applications Zehra Edis, Samir Haj Bloukh, Hamed Abusara, Iman Haj Bloukh, Ibrahim Haj Bloukh https://link.springer.com/book/10.1007/978-981-97-1908-2 ISBN 978-981-97-1907-5 ISBN 978-981-97-1908-2 (eBook) https://doi.org/10.1007/978-981-97-1908-2 Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Antimicrobial resistance (AMR) is a growing concern for the future of mankind. Common antibiotics fail in the treatment of microbial infections at an alarming rate. Morbidity and mortality rates increase, especially among immune-compromised populations. Medicinal plants and their essential oils, as well as iodine could be potential solutions against resistant pathogens. These natural antimicrobials abate microbial proliferation, especially in synergistic combinations. We performed a simple, one-pot synthesis to prepare our formulation with polyvinylpyrrolidone (PVP)-complexed iodine (I2), Thymus Vulgaris L. (Thyme), and Aloe Barbadensis Miller (AV). SEM/EDS, UV-vis, Raman, FTIR, and XRD analyses verified the purity, composition, and morphology of AV-PVP-Thyme-I2. We investigated the inhibitory action of the bio-formulation AV-PVP-Thyme-I2 against 10 selected reference pathogens on impregnated sterile discs, surgical sutures, cotton gauze bandages, surgical face masks, and KN95 masks. The antimicrobial properties of AV-PVP-Thyme-I2 were studied by disc diffusion methods and compared with those of the antibiotics gentamycin and nystatin. The results confirm AV-PVP-Thyme-I2 as a strong antifungal and antibacterial agent against the majority of the tested microorganisms with excellent results on cotton bandages and face masks. After storing AV-PVP-Thyme-I2 for 18 months, the inhibitory action was augmented compared to the fresh formulation. Consequently, we suggest AV-PVP-Thyme-I2 as an antimicrobial agent against wound infections and a spray-on contact killing agent. Edis, Z.; Bloukh, S.H.; Sara, H.A.; Bloukh, I.H. Green Synthesized Polymeric Iodophors with Thyme as Antimicrobial Agents. Int. J. Mol. Sci. 2024, 25, 1133. https://doi.org/10.3390/ijms25021133 https://www.scopus.com/record/display.uri?eid=2-s2.0-85183247210&origin=resultslist
With the quick commercial expansion, demand for cosmetics made with natural materials has been rising steadily over time. A potential replacement that is substantially safer than the chemical ingredients would be a deep-sea water (DSW) based cosmetic that mostly consists of organic and biomaterial elements. This research attempts to demonstrate that DSW can be a good alternative to chemical cosmetics by examining its antibacterial capabilities. The antibacterial properties of DSW were ascertained using the well diffusion method and the Mueller Hinton Agar plate technique. Escherichia coli and Staphylococcus aureus, two of the most prevalent bacteria on human skin, were used in the antimicrobial tests. The hollow zones that were produced as a result of the inhibition zones were assessed to demonstrate their potential as a replacement for numerous chemical-based products. This study will serve as a foundation for the widespread use of DSW, which promises to be a safe and sustainable ingredient, in future cosmetics. Govinraj Ravi Chandran, Daniel Joe Dailin, Nor Hasmaliana Abdul Manas, Hesham Ali El-Ensashy, Mustafa Man, Zehra Edis, Widya Fatriasari, and Nur Izyan Wan Azelee Antimicrobial Properties of Deep-Sea Water Towards Escherichia coli and Staphylococcus aureus Bioprocessing and Biomass Technology 2:1 (2023) 13 – 17 https://bioprocessing.utm.my/index.php/bioprocessing https://doi.org/10.11113/bioprocessing.v2n1.22
In the biological systems, exposure to nanoparticles (NPs) can cause complicated interactions with proteins, the formation of protein corona and structural changes to proteins. These changes depend not only on NP physicochemical properties, but also on the intrinsic stability of protein molecules. Although, the formation of protein corona on the surface of NPs and the underlying mechanisms have been fully explored in various studies, no comprehensive review has discussed the direct biochemical and biophysical interactions between NPs and blood proteins, particularly transferrin. In this review, we first discussed the interaction of NPs with proteins to comprehend the effects of physicochemical properties of NPs on protein structure. We then overviewed the transferrin structure and its direct interaction with NPs to explore transferrin stability and its iron ion (Fe3+) release behavior. Afterwards, we surveyed the various biological functions of transferrin, such as Fe3+ binding, receptor binding, antibacterial activity, growth, differentiation, and coagulation, followed by the application of transferrin-modified NPs in the development of drug delivery systems for cancer therapy. We believe that this study can provide useful insight into the design and development of bioconjugates containing NP-transferrin for potential biomedical applications. Khan, S.; Cho, W.C.; Hussain, A.; Azimi, S.; Babadaei, M.M.N.; Bloukh, S.H.; Edis, Z.; Saeed, M.; ten Hagen, T.L.M.; Ahmadi, H.; Ale-Ebrahim, M.; Jaragh-Alhadad, L.A.; Khan, R.H.; Falahati, M.; Zhang, X.; Bai, Q. The interaction mechanism of plasma iron transport protein transferrin with nanoparticles International Journal of Biological Macromolecules 2023, 240, 124441. DOI: 10.1016/j.ijbiomac.2023.124441 https://doi.org/10.1016/j.ijbiomac.2023.124441 Review https://www.scopus.com/record/display.uri?eid=2-s2.0-85152639463&origin=resultslist&sort=plf-f