Dr. Zehra Edis Born in Cologne, Germany. Education: 1. Vordiplom (BSc) at the University of Cologne, Germany. 2. Diplom (MSc) at the University of Cologne. „Investigations on the Synthesis of Fluororganogallium-Compounds“. 3. Ph.D. at the University of Cologne, Germany. „Polyiodides of 12-Crown-4 Complexes with Alkali cations“. Available at www.ub.uni-koeln.de/ediss/archiv/1999/11v3508.pdf. Ph.D with Scholarship of the Graduiertenkolleg „Classification of phase transitions in crystalline compounds on account of structural and physical anomalies“. Degrees BSc, MSc and Ph.D. with (magna cum laude) "Excellent" in Chemistry from the University of Cologne, Germany. Assistant Professor in Ajman University, UAE, since February 2014. Associate Professor since September 2021. Working with the Center of Medical and Bio-allied Sciences Research, Ajman University. More than 42 publications. Research Interests: 1. Research Grants as Principal Investigator in Research grant from AU Graduate and Research Studies since 2017 Antimicrobial activity of polyiodide complexes of sandwiched Group I crown ethers-Optimization on 12-crown-4 and Computational analysis. Cooperation with Mauritius University. 2. Antimicrobial activity of 12-crown-4 polyiodides with MI (M=Li, Na, K, Rb, Cs, Cu). 3. Antimicrobial activity of Copper Iodide Nanoparticles and Polyiodides with polymers. 4. Antibacterial activity of Polyiodides of Cupric iodide and Alkalimetaliodides MI (M=Li, Na, K) on E-Coli mediated by DNA and membrane damage. 5. Vitamin D Deficiency. 6. Biosynthesis, characterization and antimicrobial activities of TCA-PI-Silver nanoparticles. From chemical reduction to green synthesis. 7. Plants as natural sources for antimicrobials. 8. Polyiodides and their antimicrobial activities due to halogen bonding. 9. Nanomaterials as drug carriers and antimicrobials 10. Plant-iodine-biopolymers and their antimicrobial activities
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The non-toxic inorganic antimicrobial agents iodine (I2) and copper (Cu) are interesting alterna-tives for biocidal applications. Iodine is broad-spectrum antimicrobial agent but its use is over-shadowed by compound instability, uncontrolled iodine release and short-term effectiveness. These disadvantages can be reduced by forming complex-stabilized, polymeric polyiodides. In a facile, in-vitro synthesis we prepared the copper-pentaiodide complex [Cu(H2O)6(12-crown-4)5]I6 2I2, investigated its structure and antimicrobial properties. The chemical structure of the com-pound has been verified. We used agar well and disc-diffusion method assays against nine mi-crobial reference strains in comparison to common antibiotics. The stable complex revealed ex-cellent inhibition zones against C. albicans WDCM 00054, and strong antibacterial activities against several pathogens. [Cu(H2O)6(12-crown-4)5]I6 2I2 is a strong antimicrobial agent with an inter-esting crystal structure consisting of complexes located on an inversion center and surrounded by six 12-crown-4 molecules forming a cationic substructure. The six 12-crown-4 molecules form hydrogen bonds with the central Cu(H2O)6 . The anionic substructure is a halogen bonded pol-ymer which is formed by formal I5− repetition units. The topology of this chain-type polyiodide is unique. The I5− repetition units can be understood as a triodide anion connected to two iodine molecules.
Despite the promising medicinal properties, berberine (BBR), due to its relatively poor solubility in plasma, low bio-stability and limited bioavailability is not used broadly in clinical stages. Due to these drawbacks, drug delivery systems (DDSs) based on nanoscale natural polysaccharides, are applied to address these concerns. Natural polymers are biodegradable, non-immunogenic, biocompatible, and non-toxic agents that are capable of trapping large amounts of hydrophobic compounds in relatively small volumes. The use of nanoscale natural polysaccharide improves the stability and pharmacokinetics of the small molecules and, consequently, increases the therapeutic effects and reduces the side effects of the small molecules. Therefore, this paper presents an overview of the different methods used for increasing the BBR solubility and bioavailability. Afterwards, the pharmacodynamic and pharmacokinetic of BBR nanostructures were discussed followed by the introduction of natural polysaccharides of plant (cyclodextrines, glucomannan), the shells of crustaceans (chitosan), and the cell wall of brown marine algae (alginate)-based origins used to improve the dissolution rate of poorly soluble BBR and their anticancer and antibacterial properties. Finally, the anticancer and antibacterial mechanisms of free BBR and BBR nanostructures were surveyed. In conclusion, this review may pave the way for providing some useful data in the development of BBR-based platforms for clinical applications.
The advancement in early diagnosis and precise treatments options result in more predictable and powerful health care modalities. Aptamers are known as nucleic acid structures with three-dimensional conformation to selectively bind a target site. Physicochemical properties of aptamers, their conjugation with nanoparticles (NPs) in theranostics applications and their internalization have been found to be of interest in development of aptamer-based drug delivery systems. Therefore, we aimed to present an overview on the structure and generation of aptamers followed by advantages of aptamers-conjugated NPs and their theranostics applications in various diseases such as oncology, inflammatory diseases and viral diseases. Afterward, we discussed several reports on the internalization approaches of aptamers, efficiency of aptamers vs. their analogous, and implications of aptamers in clinical trials. Finally, we discussed the current challenges and future perspectives of actively targeted aptamers for clinical application. In conclusion, this review may hold a great promise for development of aptamer-based therapeutic platforms in clinical trials.
Khan S., Cho W.C., Jaragh-Alhadad L.A., Tarharoudi R., Bloukh S.H., Edis Z., Sari S., Falahati M., ten Hagen T.L.M., Khan R.H., Bai Q. Nano-bio interaction: An overview on the biochemical binding of DNA to inorganic nanoparticles for the development of anticancer and antibacterial nano-platforms International Journal of Biological Macromolecules 2023, 225, pp. 544 – 556. DOI: 10.1016/j.ijbiomac.2022.11.110 https://doi.org/10.1016/j.ijbiomac.2022.11.110
Edis, Z.; Bloukh, S.H. Antimicrobial V-Shaped Copper(II) Pentaiodide: Insights to Bonding Pattern and Susceptibility. Molecules 2022, 27, 6437. https://doi.org/10.3390/molecules27196437
Zhang, W.; Cho, W.C.; Bloukh, S.H.; Edis, Z.; Du, W.; He, Y.; Hu, H.Y.; ten Hagen, T.L.M.; Falahati, M. An overview on the exploring the interaction of inorganic nanoparticles with microtubules for the advancement of cancer therapeutics International Journal of Biological Macromolecules 2022, 212, pp. 358 – 369.. DOI: 10.1016/j.ijbiomac.2022.05.150 https://doi.org/10.1016/j.ijbiomac.2022.05.150
Sharifi, M.; Cho, W.C.; Ansariesfahani, A.; Tarharoudi, R.; Malekisarvar, H.; Sari, S.; Bloukh, S.H.; Edis, Z.; Amin, M.; Gleghorn, J.P.; et al. An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment. Cancers 2022, 14, 2868. https://doi.org/10.3390/cancers14122868
Suliman Khan, Majid Sharifi, Jason P. Gleghorn, Mohammad Mahdi Nejadi Babadaei, Samir Haj Bloukh, Zehra Edis, Mohammadreza Amin, Qian Bai, Timo L.M. ten Hagen, Mojtaba Falahati, William C. Cho Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy. Journal of Controlled Release 2022, 348, 127-147, https://doi.org/10.1016/j.jconrel.2022.05.055
Edis, Z.; Bloukh, S.H.; Sara, H.A.; Azelee, N.I.W. Antimicrobial Biomaterial on Sutures, Bandages and Face Masks with Potential for Infection Control. Polymers 2022, 14, 1932. https://doi.org/10.3390/polym14101932
Desai, A.S.; Singh, A.; Edis, Z.; Haj Bloukh, S.; Shah, P.; Pandey, B.; Agrawal, N.; Bhagat, N. An In Vitro and In Vivo Study of the Efficacy and Toxicity of Plant-Extract-Derived Silver Nanoparticles. J. Funct. Biomater. 2022, 13, 54. https://doi.org/10.3390/jfb13020054.