Dr. Zaw Myo Hein is an Assistant Professor of Anatomy at the College of Medicine, Ajman University. He earned his MBBS from the University of Medicine-2, Yangon, Myanmar, and initially practiced as a physician in various hospitals. Dr. Hein also served as a faculty member in the Department of Anatomy at the University of Medicine-1, Yangon, Myanmar. He completed his PhD in Neuroscience at Mahidol University, Thailand, with a focus on neurotoxicity, neuroinflammation, cognitive function, and the neuroprotective potential of melatonin and aquaporins in the brain. His research has earned him several grants and accolades, including a prestigious PhD scholarship from the Norwegian Programme for Capacity Development. A proactive and dynamic scholar, Dr. Hein has collaborated with esteemed institutions such as the Albert Einstein College of Medicine, New York, and the University of Oslo. He has presented his groundbreaking research at major international conferences, including the IBRO World Congress, the Society for Neuroscience Conference, and the American Association for Anatomy Conference.
Neuron-Glial2 (NG2) expressing cells are described as the oligodendrocyte precursor cells in the brain. This study aimed to investigate the possible involvement of NG2 cells under the methamphetamine (METH)-induced neurotoxicity and neuroprotective capacity of melatonin. The results showed that the levels of NG2 in rat brain gradually increase from postnatal day 0 to postnatal day 8 and then the lower levels of NG2 are shown in adults. In adult rats, the levels of NG2 and COX-2 in the brain were significantly increased in lipopolysaccharide treatment. Pretreatment of 10 mg/kg melatonin prior to treating with METH was able to reduce an increase in the levels of NG2 and activation in astrocyte and microglia. These findings would extend the contribution of NG2 expressing cells in the adult brain during pathological conditions such as neuroinflammation.