Dr. Mohamed Abdulaziz Mohamed Elsayed graduated from the Faculty of Dentistry, Mansoura University, Egypt, in 1990, where he ranked first in his class. He obtained a Master's degree in Conservative Dentistry from the same university in 1996 and a Ph.D. in Endodontics from Mainz University in 2002. Dr. Elsayed worked as an Assistant Professor at Mansoura University from 2002 to 2004 before serving as an Endodontic Consultant in various hospitals across the Gulf region. He joined Ajman University in 2005 and is currently an Associate Professor of Endodontics in the Master of Restorative Program. His research interests focus on the field of Endodontics, particularly new obturation materials. Clinically, he specializes in microscopic Endodontic treatments using a surgical microscope.
logo International Journal of Dentistry + Journal Menu PDF Article Sections Research Article | Open Access Volume 2021 |Article ID 6550054 | https://doi.org/10.1155/2021/6550054 Show citation Comparing the Antifungal Effect of Sodium Hypochlorite Gel versus Different Types of Root Canal Medicaments at Different Time Intervals Using the Agar Diffusion Test: An In Vitro Study Mohamed El Sayed ,1,2 Nikta Ghanerad ,1 Zeinab Shabanpour ,1 Mahin Shabanpoor ,1 and Fatemeh Rahimi 1 Show more Academic Editor: Cesar Rogério Pucci Published 13 Dec 2021 Abstract Aims. The purpose of this study was to compare the antifungal activity of sodium hypochlorite gel to those of four intracanal medicaments at various time intervals. Materials and Methods. The agar well diffusion technique was utilized to test the antifungal activity of the following medicaments against Candida albinans (C. albicans): sodium hypochlorite gel, chlorhexidine gel, calcium hydroxide paste, Ledermix, and Diapex Plus. The inhibition zone related to each medicine was measured in millimeter after 24, 48, and 72 hours of incubation at 37°C. The data were analyzed using one-way ANOVA and Games–Howell tests, at a significance level of . Results. Except for Ledermix and Diapex Plus, which had no antifungal action, all of the medicaments showed varied inhibitory zones for C. albicans. At all periods, the NaOCl gel had the most significant inhibition zones, followed by the CHX gel and calcium hydroxide. At all time intervals, the NaOCl gel demonstrated comparable antifungal efficacy. When compared to a 24-hour time interval, the CHX gel showed an increased antifungal activity at the 48-hour and 72-hour intervals. Calcium hydroxide, on the other hand, showed a decrease in its antifungal activity at the 72-hour interval. Conclusion. The antifungal activity of sodium hypochlorite gel was the highest among the investigated medicaments. Chlorhexidine gel's antifungal activity improved over time, whereas calcium hydroxide's antifungal activity declined. Diapex Plus and Ledermix did not have any antifungal properties.